This web page was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison. https://genetics564.weebly.com/
What is Chemical Genomics?
Chemical Genomics is the study of how small molecules affect cells, cellular components, genes, proteins, or organisms and their functions. Small molecules include drugs, proteins, chemical compounds, lipids, etc. Figure 1 depicts the mechanism that is used to perform the screens. The tests can show phenotypes or small chemical interactions. This information can be useful in determining possible therapeutic methods or insight into what may cause a phenotype. There is often an advantage of using this method for drug discovery because they are already FDA approved.
Discussion
Upon a search with PubChem, there were no significant known small molecule interactions or phenotypes found. This is likely due to the fact that the mutation leads to the inability to break down an amino acid. Therefore, the only rescue for that phenotype would be something else that would be able to break down the branched chain amino acids. If this was found, it could point to a cure for MSUD that does not change the diet of a patient.
References:
Sources:
MacBeath G. (2001). Chemical genomics: what will it take and who gets to play?. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138939/#!po=52.5000
Bredel, M., Jacoby, E. (2004). Chemogenomics: an emerging strategy for rapid target and drug discovery. Retrieved from: https://www.nature.com/articles/nrg1317
Compound Libraries. (2019). Enzo. Retrieved from: http://www.enzolifesciences.com/platforms/small-molecule-chemistry/compound-libraries/
Images:
Header: image.axd
MacBeath G. (2001). Chemical genomics: what will it take and who gets to play?. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138939/#!po=52.5000
Bredel, M., Jacoby, E. (2004). Chemogenomics: an emerging strategy for rapid target and drug discovery. Retrieved from: https://www.nature.com/articles/nrg1317
Compound Libraries. (2019). Enzo. Retrieved from: http://www.enzolifesciences.com/platforms/small-molecule-chemistry/compound-libraries/
Images:
Header: image.axd